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Animal testing in science would be phased out faster under a new plan to increase the use of artificial intelligence and 3D bioprinted human tissues, a UK minister has said. The Guardian: The roadmap unveiled by the science minister, Patrick Vallance, backs replacing certain animal tests that are still used where necessary to determine the safety of products such as life-saving vaccines and the impact pesticides have on living beings and the environment. The strategy says phasing out the use of animals in science can only happen when reliable and effective alternative methods with the same level of safety for human exposure can replace them. The government said new funding for researchers and streamlined regulation would help develop methods such as organ-on-a-chip systems -- tiny devices that mimic how human organs work using real human cells. Greater use of AI to analyse vast amounts of data about molecules and predict whether new medicines will be safe and work well on humans would be deployed, while 3D bioprinted tissues could create realistic human tissue samples, from skin to liver, for testing. Other plans under the strategy include an end to regulatory testing on animals to assess the potential for skin and eye irritation and skin sensitisation by the end of 2026. By 2027, researchers are expected under the strategy to end tests of the strength of botox on mice, while by 2030 pharmacokinetic studies -- which track how a drug moves through the body over time -- on dogs and non-human primates will be reduced.

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BrianFagioli writes: Mozilla has released Firefox 145.0, and the standout change in this version is the official end of support for 32-bit Linux systems. Users on 32-bit distributions will no longer receive updates and are being encouraged to switch to the 64-bit build to continue getting security patches and new features. While most major Linux distributions have already moved past 32-bit support, this shift will still impact older hardware users and lightweight community projects that have held on to 32-bit for the sake of performance or preservation. The rest of the update introduces features such as built-in PDF comments, improved fingerprinting resistance for private browsing, tab group previews, password management in the sidebar, and minor UI refinements. Firefox also now compresses local translation models with Zstandard to reduce storage needs. But the end of 32-bit Linux support is the change that will leave the biggest mark, signaling another step toward a web ecosystem firmly centered on 64-bit computing.

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The furious push by AI hyperscalers to build out data centers will need about $1.5 trillion of investment-grade bonds over the next five years and extensive funding from every other corner of the market, according to an analysis by JPMorgan. From a report: "The question is not 'which market will finance the AI-boom?' Rather, the question is 'how will financings be structured to access every capital market?'" according to strategists led by Tarek Hamid. Leveraged finance is primed to provide around $150 billion over the next half decade, they said. Even with funding from the investment-grade and high-yield bond markets, as well as up to $40 billion per year in data-center securitizations, it will still be insufficient to meet demand, the strategists added. Private credit and governments could help cover a remaining $1.4 trillion funding gap, the report estimates. The bank calculates an at least $5 trillion tab that could climb as high as $7 trillion, singlehandedly driving a reacceleration in growth in the bond and syndicated loan markets, the strategists wrote in a report Monday. The analysts project $300 billion in high-grade bonds going toward AI data centers next year. That could account for nearly one fifth of total issuance in that market, which a report from Barclays estimates will grow to $1.6 trillion.

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The iPad Pro went on sale ten years ago, launching with a 12.9-inch screen that Apple believed would redefine computing through size alone. The company initially resisted making the device a laptop replacement and maintained strict limitations on multitasking, browser capabilities, and app installation. Over the past decade, Apple reversed course. The iPad Pro gained USB-C ports, external drive support, keyboard and trackpad accessories, and an improved Files app. The current M5 model includes OLED screens in 13- and 11-inch sizes. iPadOS 26 added free-form multitasking, a menu bar and the Preview app. The webcam now sits in landscape orientation. Despite these advances, the device remains constrained by App Store-only software installation, The Verge writes, limited system access, and the absence of desktop-class browsers. Apple spent years positioning the iPad as a third category between phones and computers. The hardware and accessories now support full computer functionality, but artificial software limitations remain in place.

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Apple has launched the iPhone Pocket, a knitted bag designed to hold iPhones. The limited edition collaboration with Japanese designer Issey Miyake costs $229.95 for the crossbody version. A shorter version is priced at $149.95. Apple said the 3D-knitted design was inspired by "a piece of cloth" and was born from the idea of creating an additional pocket for any iPhone and small everyday items. Yoshiyuki Miyamae, design director at Miyake Design Studio, said the product "speaks to the bond between iPhone and its user" and explores "the joy of wearing iPhone in your own way." Steve Jobs mocked similar $29 iPod Socks as "a revolutionary new product" in 2004.

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Sam Altman's Tools for Humanity has verified around 17.5 million people through its iris-scanning Orb device. The company has set a goal of reaching 1 billion users, so it is less than 2% of the way there. The startup has raised $240 million from investors including Andreessen Horowitz, Bain Capital and Khosla Ventures. PitchBook estimates its valuation at $2.5 billion. The Orb is a volleyball-sized metal sphere that scans irises to generate a World ID. Users can claim tokens of the cryptocurrency Worldcoin, currently worth around 80 cents per coin. Business Insider spoke to former Tools for Humanity employees, a former Orb operator from Kenya, and a former head of operations in Mexico City. Some questioned whether the company had a clear long-term strategy. Nick Maynard, vice president of fintech market research at Juniper Research, said he does not see a killer use case that will drive major traction. The company also continues to face regulatory headwinds. In October, agencies in the Philippines, Colombia and Thailand took action to halt operations. German authorities determined last year that the company's data protection measures would not be sufficient to protect against cybercriminals or state attackers.

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Samsung is rolling out new conversational AI across its 2025 TVs that lets users ask questions about what's on the screen and beyond it. From a report: First announced in September, the generative AI update is rolling out now with support for several languages. Vision AI Companion is based on an upgraded, generative AI-based version of Samsung's virtual assistant Bixby. Samsung suggests you can use it to ask questions about on-screen content -- what that actor is famous for, who painted that artwork, or what the final score was in a football game. It can go beyond that though, offering TV and movie recommendations along with cooking advice, travel tips, and local restaurant discovery.

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The UK and China today signed a new bilateral agreement on scientific collaboration [non-paywalled source], narrowing the scope of their partnership to exclude sensitive technologies. Lord Patrick Vallance, Britain's science and technology minister, met his Chinese counterpart Chen Jiachang in Beijing and agreed to focus cooperation on health, climate, planetary sciences, and agriculture. The previous agreement from 2017 had included satellites, remote sensing technology and robotics. Those fields are absent from the new accord. The countries announced no new funding for joint research. Vallance said the UK had "deliberately gone for areas which we think are not carrying such a security risk."

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Multiple security issues have been found in the Mozilla Firefox web browser, which could potentially result in the execution of arbitrary code or bypass of the same-origin policy.

https://security-tracker.debian.org/tracker/DSA-6054-1

Longtime Slashdot reader theodp writes: The UK Department for Education is "replacing its narrowly focused computer science GCSE with a broader, future-facing computing GCSE [General Certificate of Secondary Education] and exploring a new qualification in data science and AI for 16-18-year-olds." The move aims to correct unintended consequences of a shift made more than a decade ago from the existing ICT (Information and Communications Technology) curriculum, which focused on basic digital skills, to a more rigorous Computer Science curriculum at the behest of major tech firms and advocacy groups to address concerns about the UK's programming talent pipeline. The UK pivot from rigorous CS to AI literacy comes as tech-backed nonprofit Code.org leads a similar shift in the U.S., pivoting from its original 2013 mission calling for rigorous CS for U.S. K-12 students to a new mission that embraces AI literacy. Code.org next month will replace its flagship Hour of Code event with a new Hour of AI "designed to bring AI education into the mainstream" with the support of its partners, including Microsoft, Google, and Amazon. Code.org has pledged to engage 25 million learners with the new Hour of AI this school year.

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China's CO2 emissions have been flat or falling for 18 months, "adding evidence to the hope that the world's biggest polluter has managed to hit its target of peak CO2 emissions well ahead of schedule," reports the Guardian. From the report: Rapid increases in the deployment of solar and wind power generation -- which grew by 46% and 11% respectively in the third quarter of this year -- meant the country's energy sector emissions remained flat, even as the demand for electricity increased. China added 240GW of solar capacity in the first nine months of this year, and 61GW of wind, putting it on track for another renewable record in 2025. Last year, the country installed 333GW of solar power, more than the rest of the world combined. [...] The analysis by the Centre for Research on Energy and Clean Air (Crea), for the science and climate policy website Carbon Brief, found China's CO2 emissions were unchanged from a year earlier in the third quarter of 2025, thanks in part to declining emissions in the travel, cement and steel industries. But China has a record of underpromising and overdelivering on climate targets. Li Shuo, the director of the China Climate Hub at the Asia Society Policy Institute, a US-based thinktank, said in a recent note that the latest Chinese climate targets should be seen as a baseline and not a ceiling.

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An anonymous reader quotes a report from Gizmodo: It appears that Neom -- Saudi Arabia's hugely expensive, architecturally bizarre urban development project -- is floundering and close to collapse. A new report from the Financial Times cites high-level sources within the project to paint a picture of dysfunction and failure at the heart of the quixotic effort. Neom was envisioned as a vast series of fantastical urban developments spread across the coast of the Red Sea. At the center of the project is The Line -- a proposed 105-mile-long city which developers had initially projected could house as many as 9 million people by the year 2030. The Line is defined by bizarre architectural flourishes that, as the story notes, have seemed impossible even to the execs tasked with making them a reality. One such addition is an upside-down building, dubbed "the chandelier," that is supposed to hang over a "gateway" marina to the city: "As architects worked through the plans, the chandelier began to seem implausible. One recalled warning Tarek Qaddumi, The Line's executive director, of the difficulty of suspending a 30-story building upside down from a bridge hundreds of metres in the air. 'You do realize the earth is spinning? And that tall towers sway?' he said. The chandelier, the architect explained, could 'start to move like a pendulum,' then 'pick up speed,' and eventually 'break off,' crashing into the marina below." Yes, that doesn't sound great. Now, according to those sources the FT talked to, the project is looking more and more like a hugely expensive pipe dream that will never come to pass: "Today, with at least $50 billion spent, the desert is pock-marked with piling, and deep trenches stretch across the landscape. But Prince Mohammed, who chairs Neom, has dramatically scaled back the first phase of the plans. Neom told the FT that The Line remained 'a strategic priority' that would ultimately 'provide a new blueprint for humanity by changing the way people live.' But they described it as a 'multi-generational development of unprecedented scale and complexity.'" The outlet interviewed workers on the project who seem to feel that it's only a matter of time before the project is declared DOA: "While Neom employees say that much of The Line might still be technically buildable, they are not convinced anyone is ready to pay for it. Construction work across Neom has slowed, with the desert ski resort Trojena, the intended venue for the 2029 Asian Winter Games, one of the few sites still moving ahead at pace ... one former employee has said that everyone knows the project won't work; it is now just a matter of letting MBS down gently." Chief among the project's problems is the fact that, as Neom's bizarre developments have failed to materialize, it has become increasingly difficult to encourage investors to put up money for the absurdly expensive project. FT notes: "Senior executives were constantly asking for more money, but The Line was competing with other Neom projects. Some wealthy Saudi families put modest sums into the project, but the large investments Riyadh hoped to lure from foreign backers never materialized." The lack of adequate funding coming in has led a senior construction manager to tell FT that he feels the Line will never be built.

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