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A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. Nature: The child's mother took the gene-targeting drug during late pregnancy, and the child continues to take it. The "baby has been effectively treated, with no manifestations of the condition," says Michelle Farrar, a paediatric neurologist at UNSW Sydney in Australia. The results were published in the New England Journal of Medicine yesterday. The child was conceived with a genetic condition known as spinal muscular atrophy, which affects motor neurons that control movement, and leads to progressive muscle weakening. About one in every 10,000 births have some form of the condition -- making it a leading genetic cause of death in infants and children. In its most severe form, as in the case of this child, individuals lack both copies of the SMN1 gene, and have only one or two copies of a neighbouring gene, SMN2, that partially compensates for that deficiency. As a result, the body does not produce enough of the protein required for maintaining motor neurons in the spinal cord and brainstem. This protein is most important in the second and third trimesters, and the first few months of life. Babies with severe disease don't usually live past their third birthday.

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Amazon will discontinue its workplace communications platform Chime in February 2026 and has stopped accepting new customers, the company's cloud division AWS said in a blog post. The service, which Amazon employees widely used for video calls, messaging and business communications, is among several products being phased out. The company also recently shuttered Inspire, its TikTok-style video feed feature in its mobile app, and announced plans to shut down its Android app store earlier today.

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Chinese hospitals dominate a first-ever analysis of scientific paper retractions worldwide, with some institutions having retraction rates 50 times higher than the global average, according to data published in Nature. Jining First People's Hospital in Shandong leads with more than 5% of its research output from 2014-2024 being retracted -- over 100 papers. The hospital had disciplined 35 researchers for publication fraud in late 2021 amid a broader Chinese government crackdown on paper mills selling fake manuscripts. The analysis, based on data from three research integrity firms, found that about 60% of retracted articles over the past decade had authors affiliated with Chinese institutions. Other retraction hotspots include universities in Saudi Arabia, India, Pakistan and Ethiopia. While retractions remain rare globally, affecting fewer than 0.1% of published papers, rates have tripled over the past decade. In 2023, over 10,000 papers were retracted, mostly from journals owned by publisher Wiley's now-closed Hindawi subsidiary following widespread peer review fraud. The surge in retractions partly reflects increased scrutiny from research integrity experts who spot problematic papers, rather than definitively indicating which institutions produce fraudulent work, according to Ivan Oransky, co-founder of Retraction Watch.

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Melting glaciers have caused almost 2cm of sea level rise this century alone, a decades-long study has revealed. From a report: The research shows the world's glaciers collectively lost 6.542tn tonnes of ice between 2000 and 2023, causing an 18mm (0.7in) rise in global sea levels. The world's glaciers lost an average of 273bn tonnes of ice every year -- the equivalent of 30 years of water consumption by the entire global population. The assessment, led by scientists from the University of Edinburgh and the University of Zurich, found that so far this century, glaciers have lost approximately 5% of their total volume. Regional losses were highly variable; the Antarctic and subantarctic islands lost 2% of their volume but central Europe's glaciers lost 39%. "These numbers are staggering. They serve as a reminder that things are changing fast in some regions," said Prof Noel Gourmelen, the co-lead author of the study and personal chair of Earth observation at the University of Edinburgh's school of geosciences. A stark contrast in the amount of ice lost each decade was also discovered, with 36% more ice having melted between 2012 and 2023 compared with the previous decade.

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Advanced AI models are increasingly resorting to deceptive tactics when facing defeat, according to a study released by Palisade Research. The research found that OpenAI's o1-preview model attempted to hack its opponent in 37% of chess matches against Stockfish, a superior chess engine, succeeding 6% of the time. Another AI model, DeepSeek R1, tried to cheat in 11% of games without being prompted. The behavior stems from new AI training methods using large-scale reinforcement learning, which teaches models to solve problems through trial and error rather than simply mimicking human language, the researchers said. "As you train models and reinforce them for solving difficult challenges, you train them to be relentless," said Jeffrey Ladish, executive director at Palisade Research and study co-author. The findings add to mounting concerns about AI safety, following incidents where o1-preview bypassed OpenAI's internal tests and, in a separate December incident, attempted to copy itself to a new server when faced with deactivation.

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Malaysia is aggressively expanding its data center capacity, positioning itself as Southeast Asia's fastest-growing market with planned investments exceeding $31 billion in the first 10 months of 2024, triple the amount from 2023. The country's southern Johor province is set to host at least 1.6 gigawatts of data center capacity, up from nearly zero in 2019. Twenty-two mostly foreign data centers already occupy 21 hectares, with more under construction. The push comes as neighboring Singapore paused new data center construction in 2019 due to resource constraints. Some experts are warning the expansion could strain Malaysia's power and water resources, with data center power demand potentially reaching 5 gigawatts by 2035 - more than half the country's current renewable capacity. The facilities, operated by companies including Microsoft, Equinix and China's GDS Holdings, primarily service East Asia, China and Europe rather than domestic users.

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Security issues were discovered in Chromium which could result in the execution of arbitrary code, denial of service, or information disclosure.

https://security-tracker.debian.org/tracker/DSA-5869-1

An anonymous reader quotes a report from New Atlas: New research by Purdue University, the latest in a series of Purdue-led studies, examined how scented products -- in this case, flame-free candles -- are a significant source of nanosized particles small enough to get deep into your lungs, posing a potential risk to respiratory health [...] Scented wax melts are marketed as a flameless, smoke-free, non-toxic alternative to traditional candles, a safer way of making your home or office smell nice. To assess the truth of these claims, the researchers comprehensively measured the nanoparticles formed when they warmed wax melts in their mechanically ventilated test house. The tiny house is actually an architectural engineering laboratory called the Purdue Zero Energy Design Guidance for Engineers (zEDGE) lab. Designed and engineered to test the energy efficiency of a larger building, it's full of sensors that monitor the impact of everyday activities on indoor air quality. The researchers knew from their previous research that new nanoparticle formation was initiated by terpenes -- aromatic compounds that determine the smell of things like plants and herbs -- released from the melts and reacting with indoor atmospheric ozone (O3). They'd found that activities such as mopping the floor with a terpene-rich cleaning agent, using a citrus-scented air freshener, or applying scented personal care products like deodorant inside the zEDGE house resulted in pulsed terpene emissions to the indoor air within five minutes. Conversely, using essential oil diffusers or peeling citrus fruits caused a more gradual increase in terpenes. In the present study, heating the scented wax contributed significantly to the number of new particles formed in the indoor air, particularly those smaller than 100 nanometers (nm). The resulting atmospheric concentrations were over one million nanoparticles per cubic centimeter (106 cm-3), which is comparable to concentrations emitted by traditional lighted candles (106 cm-3), gas stoves (105 - 107 cm-3), diesel engines (103 - 106 cm-3), and natural gas engines (106 - 107 cm-3). By comparison, there were no significant terpene emissions when unscented wax melts were heated. The researchers also examined respiratory tract deposited dose rates (RD), a useful way of studying air pollution that measures the number of particles deposited in the respiratory tract over time. They found that the new particle formation triggered by using scented wax melts indoors produced a median RD for 1.18 to 100 nm particles of 29 billion per minute (2.9 x 1010 min-1). That's about 483 million particles per second. The majority of scented-wax-melt-formed particles were deposited in the upper airways. Their small size means they can migrate between cells and enter the bloodstream, potentially reaching organs such as the brain. The study was published in the journal Environmental Science & Technology Letters.

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Amazon will discontinue its Android Appstore servicefrom August 20, 2025, ending its decade-long attempt to compete with Google's Play Store in the Android mobile ecosystem. The Amazon Appstore, launched in 2011, served as an alternative marketplace for Android users to download apps. The platform gained prominence in 2012 when Amazon began using it as the primary app store for its Kindle Fire tablets.

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The Canadian government has launched a six-year, $3.9 billion design phase for a high-speed rail project connecting Toronto and Quebec City, with electric trains reaching up to 300 km/h. Construction is expected to begin after the design phase, potentially in four to five years, but future governments could modify or cancel the project. CBC News reports: "Today I'm announcing the launch of Alto, the largest infrastructure project in Canadian history," Trudeau said from Montreal. "A reliable, efficient, high-speed rail network will be a game-changer for Canadians." Trudeau said the new rail network will run all-electric trains along 1,000 kilometers of track, reaching speeds of up to 300 km/hour, with stops in Toronto, Peterborough, Ottawa, Montreal, Laval, Trois-Rivieres and Quebec City. A government statement said the project will stimulate the economy, "boosting GDP by up to $35 billion annually, creating over 51,000 good-paying jobs during construction." Trudeau said that once built, the new high-speed rail network will take passengers from Montreal to Toronto in three hours -- about half the time it takes to drive and at double the speed of Via Rail's current trains. [...] Trudeau said the consortium Cadence -- made up of CDPQ Infra, Atkins Realis, Keolis, SYSTRA, SNCF Voyageurs and Air Canada -- was selected to build the line. The group was only informed in the last 24 hours that their bid was the best of the three submitted, according to sources that spoke to Radio-Canada. Transport Minister Anita Anand said that Alto, the Crown corporation created to oversee the project, and Cadence will be signing a contract "in the coming weeks" that will outline the first-phase design work, such as where track will be laid and where stations will be built.

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Palantir CEO Alex Karp warns of "coming swarms of autonomous robots" and urges Silicon Valley to support U.S. defense capabilities. In his book, "The Technological Republic: Hard Power, Soft Belief, and the Future of the West," Karp argues that America risks losing its military edge to geopolitical rivals who better harness commercial technology. He calls for the "engineering elite of Silicon Valley" to work with the government on national defense. The message comes as Palantir's stock has surged more than 1,800% since early 2023, pushing its market value above $292 billion -- exceeding traditional defense contractors Lockheed Martin and RTX combined. The company has expanded its military AI work since 2018, when it took over a Pentagon contract after Google employees protested their company's defense work.

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Microsoft will strip several features from Windows 11's File Explorer for European users to comply with privacy regulations, the company says. The changes, affecting Entra ID accounts in the European Economic Area, remove Recent, Favorites, Details Pane, and Recommended content sections that previously tracked user activity. These features relied on collecting user data to display recently accessed files and personalized recommendations. The privacy-focused update, part of Windows 11 preview build 26120.3281, results in a streamlined File Explorer interface.

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"[O]ur intrepid China reporter, Caiwei Chen, has identified a new trend unfolding within China's tech scene: Companies that were dominant in electric vehicles are betting big on translating that success into developing humanoid robots," writes MIT Technology Review's James O'Donnell. "I spoke with her about what she found out and what it might mean for Trump's policies and the rest of the globe..." An anonymous reader quotes an excerpt from the report: Your story looks at electric-vehicle makers in China that are starting to work on humanoid robots, but I want to ask about a crazy stat. In China, 53% of vehicles sold are either electric or hybrid, compared with 8% in the US. What explains that? Price is a huge factor -- there are countless EV brands competing at different price points, making them both affordable and high-quality. Government incentives also play a big role. In Beijing, for example, trading in an old car for an EV gets you 10,000 RMB (about $1,500), and that subsidy was recently doubled. Plus, finding public charging and battery-swapping infrastructure is much less of a hassle than in the US. You open your story noting that China's recent New Year Gala, watched by billions of people, featured a cast of humanoid robots, dancing and twirling handkerchiefs. We've covered how sometimes humanoid videos can be misleading. What did you think? I would say I was relatively impressed -- the robots showed good agility and synchronization with the music, though their movements were simpler than human dancers'. The one trick that is supposed to impress the most is the part where they twirl the handkerchief with one finger, toss it into the air, and then catch it perfectly. This is the signature of the Yangko dance, and having performed it once as a child, I can attest to how difficult the trick is even for a human! There was some skepticism on the Chinese internet about how this was achieved and whether they used additional reinforcement like a magnet or a string to secure the handkerchief, and after watching the clip too many times, I tend to agree. President Trump has already imposed tariffs on China and is planning even more. What could the implications be for China's humanoid sector? Unitree's H1 and G1 models are already available for purchase and were showcased at CES this year. Large-scale US deployment isn't happening yet, but China's lower production costs make these robots highly competitive. Given that 65% of the humanoid supply chain is in China, I wouldn't be surprised if robotics becomes the next target in the US-China tech war. In the US, humanoid robots are getting lots of investment, but there are plenty of skeptics who say they're too clunky, finicky, and expensive to serve much use in factory settings. Are attitudes different in China? Skepticism exists in China too, but I think there's more confidence in deployment, especially in factories. With an aging population and a labor shortage on the horizon, there's also growing interest in medical and caregiving applications for humanoid robots. DeepSeek revived the conversation about chips and the way the US seeks to control where the best chips end up. How do the chip wars affect humanoid-robot development in China? Training humanoid robots currently doesn't demand as much computing power as training large language models, since there isn't enough physical movement data to feed into models at scale. But as robots improve, they'll need high-performance chips, and US sanctions will be a limiting factor. Chinese chipmakers are trying to catch up, but it's a challenge.

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The SS United States, a historic ocean liner that once held the transatlantic speed record of 36 knots (41 mph / 66 kph), has departed Philadelphia to be transformed into the world's largest artificial reef off Florida's Gulf Coast. The move is part of a $10 million project to boost tourism by creating a unique diving attraction while preserving the ship's legacy as a symbol of American innovation and engineering. The Associated Press reports: The SS United States, a 1,000-foot vessel that shattered the transatlantic speed record on its maiden voyage in 1952, is being towed to Mobile, Alabama, for planned prep work before officials eventually sink it off Florida's Gulf Coast. The move comes about four months after the conservancy that oversees the ship and its landlord resolved a years-old rent dispute. Officials initially planned to move the vessel last November, but that was delayed due to concerns from the U.S. Coast Guard that the ship wasn't stable enough to make the trip. Officials in Okaloosa County on Florida's coastal Panhandle hope it will become a barnacle-encrusted standout among the county's more than 500 artificial reefs and a signature diving attraction that could generate millions of dollars annually in local tourism spending for scuba shops, charter fishing boats and hotels. Officials have said the deal to buy the ship could eventually cost more than $10 million. The lengthy process of cleaning, transporting and sinking the vessel is expected to take at least one-and-a-half years.

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Murena has launched the Murena Pixel Tablet, a de-Googled version of the Pixel Tablet that removes Google's apps and services to enhance user privacy. Priced at $549, it offers /e/OS, an alternative app store, and privacy-focused productivity tools, but lacks Google's speaker dock and direct access to the Play Store. The Verge reports: First announced last December, the Murena Pixel Tablet is available now through the company's online store for $549. That's a steep premium given Google currently sells the same 128GB version of the Pixel Tablet for $399, or $479 as part of a bundle with the charging speaker dock that Murena isn't including. Part of Murena's de-Googling of the Pixel Tablet includes the removal of the Google Play Store. You can still download apps through /e/OS' App Lounge which acts as a front-end for the Play Store allowing you to browse and get free apps anonymously without Google knowing who you are. However, downloading paid apps requires a login to a Google account. Google's various productivity apps aren't included, but the Murena Pixel Tablet comes with privacy-minded alternatives for messaging, email, maps, browsing the web, calendar, contacts, notes, and even voice recordings. In 2022, Murena launched its first smartphone with no Google apps, Google Play Services, or even the Google Assistant.

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Valve has made Team Fortress 2's full client and server code public, allowing fans to modify, extend, or rewrite the game as long as their projects remain non-commercial. Game Rant reports: Valve has made Team Fortress 2's server and client code fully public, with the studio encouraging fans to explore the game's files and make it what they want. The game's code is now available thanks to a new update to the Source SDK, which dropped earlier this week. Fans have already been creating TF2 mods for years, but what this essentially means is that fans can make brand-new games. However, there's one catch: any and all TF2 mods must be released for free. "The majority of items in the game now are thanks to the hard work of the TF2 community." Valve wrote. "To respect that, we're asking TF2 mod makers to continue to respect that connection and not to make mods that have the purpose of trying to profit off Workshop contributors' efforts." "TF2 mods may be published on the Steam Store, and after publication will appear as new games in the Steam game list," Valve continued. The new SDK update also includes new 64-bit binary support and fixes for multiplayer Source games like Half-Life 2: Deathmatch, Counter-Strike: Source, and Day of Defeat: Source. Time will only tell what fans come up with as they dig deep into the inner workings of the game, but given how passionate and talented the Team Fortress 2 community has proven to be, players can expect to see some incredible creations.

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A recently patched Palo Alto Networks vulnerability (CVE-2025-0108) is being actively exploited alongside two older flaws (CVE-2024-9474 and CVE-2025-0111), allowing attackers to gain root access to unpatched firewalls. The Register reports: This story starts with CVE-2024-9474, a 6.9-rated privilege escalation vulnerability in Palo Alto Networks PAN-OS software that allowed an OS administrator with access to the management web interface to perform actions on the firewall with root privileges. The company patched it in November 2024. Dark web intelligence services vendor Searchlight Cyber's Assetnote team investigated the patch for CVE-2024-9474 and found another authentication bypass. Palo Alto (PAN) last week fixed that problem, CVE-2025-0108, and rated it a highest urgency patch as the 8.8/10 flaw addressed an access control issue in PAN-OS's web management interface that allowed an unauthenticated attacker with network access to the management web interface to bypass authentication "and invoke certain PHP scripts." Those scripts could "negatively impact integrity and confidentiality of PAN-OS." The third flaw is CVE-2025-0111 a 7.1-rated mess also patched last week to stop authenticated attackers with network access to PAN-OS machines using their web interface to read files accessible to the "nobody" user. On Tuesday, US time, Palo A lot updated its advisory for CVE-2025-0108 with news that it's observed exploit attempts chaining CVE-2024-9474 and CVE-2025-0111 on unpatched and unsecured PAN-OS web management interfaces. The vendor's not explained how the three flaws are chained but we understand doing so allows an attacker to gain more powerful privileges and gain full root access to the firewall. PAN is urging users to upgrade their PAN-OS operating systems to versions 10.1, 10.2, 11.0, 11.1, and 11.2. A general hotfix is expected by Thursday or sooner, notes the Register.

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An anonymous reader quotes a report from Ars Technica: For a while now, many AI researchers have been working to integrate a so-called "world model" into their systems. Ideally, these models could infer a simulated understanding of how in-game objects and characters should behave based on video footage alone, then create fully interactive video that instantly simulates new playable worlds based on that understanding. Microsoft Research's new World and Human Action Model (WHAM), revealed today in a paper published in the journal Nature, shows how quickly those models have advanced in a short time. But it also shows how much further we have to go before the dream of AI crafting complete, playable gameplay footage from just some basic prompts and sample video footage becomes a reality. Much like Google's Genie model before it, WHAM starts by training on "ground truth" gameplay video and input data provided by actual players. In this case, that data comes from Bleeding Edge, a four-on-four online brawler released in 2020 by Microsoft subsidiary Ninja Theory. By collecting actual player footage since launch (as allowed under the game's user agreement), Microsoft gathered the equivalent of seven player-years' worth of gameplay video paired with real player inputs. Early in that training process, Microsoft Research's Katja Hoffman said the model would get easily confused, generating inconsistent clips that would "deteriorate [into] these blocks of color." After 1 million training updates, though, the WHAM model started showing basic understanding of complex gameplay interactions, such as a power cell item exploding after three hits from the player or the movements of a specific character's flight abilities. The results continued to improve as the researchers threw more computing resources and larger models at the problem, according to the Nature paper. To see just how well the WHAM model generated new gameplay sequences, Microsoft tested the model by giving it up to one second's worth of real gameplay footage and asking it to generate what subsequent frames would look like based on new simulated inputs. To test the model's consistency, Microsoft used actual human input strings to generate up to two minutes of new AI-generated footage, which was then compared to actual gameplay results using the Frechet Video Distance metric. Microsoft boasts that WHAM's outputs can stay broadly consistent for up to two minutes without falling apart, with simulated footage lining up well with actual footage even as items and environments come in and out of view. That's an improvement over even the "long horizon memory" of Google's Genie 2 model, which topped out at a minute of consistent footage. Microsoft also tested WHAM's ability to respond to a diverse set of randomized inputs not found in its training data. These tests showed broadly appropriate responses to many different input sequences based on human annotations of the resulting footage, even as the best models fell a bit short of the "human-to-human baseline." The most interesting result of Microsoft's WHAM tests, though, might be in the persistence of in-game objects. Microsoft provided examples of developers inserting images of new in-game objects or characters into pre-existing gameplay footage. The WHAM model could then incorporate that new image into its subsequent generated frames, with appropriate responses to player input or camera movements. With just five edited frames, the new object "persisted" appropriately in subsequent frames anywhere from 85 to 98 percent of the time, according to the Nature paper.

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Cameron John Wagenius pleaded guilty to hacking AT&T and Verizon and stealing a massive trove of phone records from the companies, according to court records filed on Wednesday. From a report: Wagenius, who was a U.S. Army soldier, pleaded guilty to two counts of "unlawful transfer of confidential phone records information" on an online forum and via an online communications platform. According to a document filed by Wagenius' lawyer, he faces a maximum fine of $250,000 and prison time of up to 10 years for each of the two counts. Wagenius was arrested and indicted last year. In January, U.S. prosecutors confirmed that the charges brought against Wagenius were linked to the indictment of Connor Moucka and John Binns, two alleged hackers whom the U.S. government accused of several data breaches against cloud computing services company Snowflake, which were among the worst hacks of 2024.

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France has upped the ante in the quest for fusion power by maintaining a plasma reaction for over 22 minutes -- a new record. From a report: The milestone was reached on February 12 at the Commissariat a lenergie atomique et aux energies alternatives (CEA) WEST Tokamak reactor. Achieving the dream of commercial fusion power is the Holy Grail of engineering and has been for 80 years. With a single gram of hydrogen isotopes yielding the energy equivalent of 11 tonnes of coal, a practical fusion reactor would hold the promise of unlimited, clean energy for humanity until the end of time. Small wonder that billions have been invested by both government and industry in the quest to make fusion power a reality. However, while fusion is relatively easy to achieve in the heart of the sun or in a hydrogen bomb, creating a practical reactor that produces more energy than is put into it is another matter entirely.

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